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This section discusses how ferroptosis amplifies inflammation, the classical and non-classical ferroptosis pathways in COPD, and the role of CS as a ferroptosis catalyst

As a reminder, in humans, eight different isoforms of GPx (GPx18), which use GSH to catalyze the reduction of hydrogen peroxide and lipid peroxides, have been identified [19, 20]: GPx1, GPx2, GPx3, GPx4, and GPx6, which contain a selenocysteine residue (SeCys) and the GPx5, GPx7, and GPx8 that do not contain SeCys but contain a Cys residue

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Aggregation of -syn and accumulation in cytoplasmic inclusions known as Lewy bodies, is the pathological hallmark of PD (Spillantini et al